Grup G
- Panathinaikos 0-3 Standard Liege
- Gol: Cisse 61, Belfodil 75, 90+3
- Ajax Amsterdam 3-2 Celta Vigo
- Gol: Dolberg 41, Ziyech 67, Younes 71 – Guidetti 79, Iago Aspas 86
Grup H
- Sporting Braga 3-1 Konyaspor
- Gol: Velazquez 34, Wilson Eduardo 45+1, Ricardo Horta 90+7 – Rangelov 30
- KAA Gent 3-5 Shakhtar Donetsk
- Gol: Coulibaly 1, Perbet 83, Milicevic 89 – Marlos 36-pen, Taison 41, Stepanenko 45+3, Fred 67, Ferreyra 87
Grup I
- OGC Nice 0-2 Red Bull Salzburg
- Gol: Hwang Hee-chan 72, 73
- Schalke 04 2-0 Krasnodar
- Gol: Junior Caicara 24, Bentaleb 28
Grup J
- PAOK 0-1 Qarabag
- Gol: Michel 69
- Fiorentina 3-0 Slovan Liberec
- Gol: Ilicic 30-pen, Kalinic 42, Cristoforo 73
Grup K
- Southampton 2-1 Inter Milan
- Gol: Van Dijk 64, Nagatomo 70-og – Icardi 33
- Sparta Praha 2-0 Hapoel Be’er Sheva
- Gol: Bitton 23-og, Lafata 38
Grup L
- Zurich 0-0 Steaua Bucuresti
- Gol: –
- Villarreal 1-2 Osmanlispor
- Gol: Rodri Hernandez 48 – Webo 8, Rusescu 75
